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Lixte Biotechnology Holdings, Inc

Other

Town of Brookhaven, USA

LIXT

Lixte Biotechnology Holdings, Inc. (Lixte) is a clinical-stage public (LIXT) pharmaceutical company dedicated to discovering drugs for more effective treatments for cancer. Lixte has identified molecular signaling pathways altered in disease states and designed compounds that can safely target them in animal models. The current drug portfolio includes inhibitors of protein phosphatases that are critical to cell division and DNA damage repair and inhibitors of protein deacetylases that regulate pathways of gene expression and protein degradation. The phosphatase inhibitors enhance the effectiveness of cytotoxic anti-cancer drugs in general as well as radiation therapy making them potentially useful for the treatment of many, if not all, cancers in combination with existing standard chemotherapy regimens and the evolving targeted cytotoxic therapies of personalized cancer medicine. The lead compound LB-100 is in Phase I trial and has the potential to be first-in-class. The deacetylase inhibitors have anti-cancer activity and in model systems correct enzymes deficiencies underlying several inborn metabolic diseases including Gaucher and von Hippel-Lindau disease and neurofibromatosis type 2. Lixte's cancer drug development strategy has led to the discovery of novel compounds with the potential to be therapeutically useful against several other important but seemingly disparate diseases. The phosphatase inhibitors are in pre-clinical development for reducing the extent of tissue damage following stroke, heart attack, and septic shock; and, the deacetylase inhibitors for prevention and treatment of neurodegenerative diseases, traumatic brain injury, and topically for fungal dermatitis .

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Mantis Innovation

Mantis Innovation

Other

Houston, USA

At Mantis Innovation, our experts provide data-driven, consultative services designed to optimize your facility, sustainability, and energy management strategies, while ultimately making your lives easier with trusted, unbiased solutions designed to generate value. Weโ€™ll guide you in making the right decision at the right time, providing ongoing support, custom solutions, and turnkey energy and facilities management. Weโ€™re focused on real risk management, real cost savings, and real carbon reductions. Our team provides managed facility services and turnkey program management with technology-enabled solutions that target the entire building footprint. Weโ€™re looking at the entire facility, inside and out, and can impact 70% of what a building operator allocates critical budget dollars toward including: - Strategic electricity and natural gas procurement, renewable energy, and demand response - Climate impact reduction and reporting, net zero strategies, sustainability planning - Roofing, solar, HVAC assessment management, pavement, building envelope, data center optimization, EV charging - Lighting/LED retrofits, HVAC/mechanical, and building automation systems improvements and implementation Our turnkey solutions maximize results at every touchpoint of facility performance. Our technology platforms make those touchpoints accurate and visceral, backed by data from billions of feet of facility space. We offer all of this with a white glove service, meaning our clients receive an unparalleled level of professionalism and care. Mantis is headquartered in Houston, Texas, with office locations across the United States from Massachusetts to Washington. Discover more about Mantis at www.mantisinnovation.com

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